Carpal Tunnel Syndrome (CTS) is the most common type of entrapment neuropathy and affects approximately 1-5% of the general population, mostly patients older than 50 years. CTS is present in various conditions and diseases and could also be an early sign of systemic transthyretin (ATTR) amyloidosis, a risk factor for amyloid cardiomyopathy. With advances in treatment of cardiac amyloidosis (CA), patient prognosis could be significantly altered with an early diagnosis. To date, few studies have analyzed the relationship between ATTR tenosynovial deposits and CTS pathogenesis. This knowledge is essential for the development of any strategy concerning early screening of cardiomyopathy or long-term follow-up of patients with CTS. Cardiac scintigraphy with bone markers provides noninvasive cardiac imaging with high specificity and sensibility in the diagnosis of ATTR CA allowing early screening of CA in patients with idiopathic CTS using the Perugini semi-quantitative grading score of cardiac uptakes following the injection of radiotracers.

The CarPoS study aims to characterize the association between idiopathic CTS and transthyretin amyloidosis and its evaluation as a predictive factor of cardiac amyloidosis.