The FabryPET project (FCT: 2023.15385.PEX) has officially started with the successful completion of the first FAPI PET scan, marking an important milestone in the study of imaging biomarkers in Fabry cardiomyopathy.
The scan was performed at the Nuclear Medicine Service of ULS São João, whose expertise was essential for implementing this advanced molecular imaging protocol. This achievement was supported by a strong collaboration with GE HealthCare and SOFIE.
FabryPET intends to deepen the knowledge of the signalling pathways involved in cardiac remodelling of human FD by comparing the proteomics data from FD myocardial biopsies with normal tissue of heart donor biopsy samples; characterize the process of cardiac remodelling by analyzing the profile of microRNAs related to hypertrophic cardiomyopathy and their diagnostic and prognostic value; and characterize the process of myocardial fibrosis using a new molecular imaging technic, determining its value in the diagnosis and prognosis of FD.
This first examination signals the beginning of active data collection and reinforces FabryPET’s role as a proof-of-concept project for fibroblast-targeted PET imaging in rare cardiac disease.
